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Clin Vaccine Immunol. 2014 Jun;21(6):787-90. doi: 10.1128/CVI.00201-14. Epub 2014 Apr 16.

Serological diagnostic assays for HIV-associated tuberculosis in sub-Saharan Africa?

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1
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, and The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa stephen.lawn@lshtm.ac.uk.

Abstract

In this issue of Clinical and Vaccine Immunology, Siev and colleagues present an evaluation of antibody responses to four immunodominant proteins of Mycobacterium tuberculosis in patients with HIV-associated pulmonary tuberculosis (TB) in South Africa (M. Siev, D. Wilson, S. Kainth, V. O. Kasprowicz, C. M. Feintuch, E. Jenny-Avital, and J. J. Achkar, 21:791-798, 2014, doi:http://dx.doi.org/10.1128/CVI.00805-13). This commentary discusses the enormous need for simple point-of-care assays for tuberculosis (TB) diagnosis in patients with and without HIV coinfection in high-burden settings and considers the potential role of serological assays and the huge challenges inherent in developing and validating such assays.

PMID:
24739979
PMCID:
PMC4054249
DOI:
10.1128/CVI.00201-14
[Indexed for MEDLINE]
Free PMC Article
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