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Nat Rev Mol Cell Biol. 2014 May;15(5):327-39. doi: 10.1038/nrm3786. Epub 2014 Apr 16.

Advances in whole-embryo imaging: a quantitative transition is underway.

Author information

1
Department of Biosystems Science and Engineering (D-BSSE), Eidgenössische Technische Hochschule (ETH) Zurich, 4058 Basel, Switzerland.
2
Laboratory for Optics and Biosciences, École Polytechnique, Centre National de la Recherche Scientifique (CNRS) UMR7645, and Institut National de la Santé et de la Recherche Médicale (INSERM) U696, 91120 Palaiseau, France.

Abstract

With the advent of imaging probes and live microscopy, developmental biologists have markedly extended our understanding of the molecular and cellular details of embryonic development. To fully comprehend the complex mechanistic framework that forms the developing organism, quantitative studies with high fidelity in space and time are now required. We discuss how integrating established, newly introduced and future imaging tools with quantitative analysis will ensure that imaging can fulfil its promise to elucidate how new life begins.

PMID:
24739741
DOI:
10.1038/nrm3786
[Indexed for MEDLINE]

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