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Nat Commun. 2014 Apr 17;5:3708. doi: 10.1038/ncomms4708.

Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.

Author information

1
1] Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin, Virchowweg 6, 10117 Berlin, Germany [2] Max Planck Institute for Experimental Medicine, Hermann-Rein-Strasse. 3, 37075 Goettingen, Germany [3].
2
1] Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin, Virchowweg 6, 10117 Berlin, Germany [2] Shemyakin and Ovchinnikov Institute for Bioorganic Chemistry RAS, Miklukho-Maklaya, Moscow 117997, Russia.
3
Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin, Virchowweg 6, 10117 Berlin, Germany.
4
Queensland Brain Institute, School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
5
Howard Hughes Medical Institute and The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

Abstract

The pyramidal neurons of the mammalian neocortex form two major types of long-range connections-corticocortical and cortico-subcortical. The transcription factors Satb2 and Ctip2 are critical regulators of neuronal cell fate that control interhemispheric versus corticofugal connections respectively. Here, we investigate the axon guidance molecules downstream of Satb2 and Ctip2 that establish these connections. We show that the expression of two Netrin1 receptors- DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively. Further, we show that the Netrin1-Unc5C/DCC interaction is involved in controlling the interhemispherical projection in a subset of early born, deep layer callosal neurons.

PMID:
24739528
PMCID:
PMC3997811
DOI:
10.1038/ncomms4708
[Indexed for MEDLINE]
Free PMC Article
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