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Oxid Med Cell Longev. 2014;2014:248786. doi: 10.1155/2014/248786. Epub 2014 Mar 5.

The protective effects of Shen-Fu injection on experimental acute pancreatitis in a rat model.

Author information

1
Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China.
2
Department of General Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang, Wuhan, Hubei 430071, China.

Abstract

OBJECTIVES:

In the present study, we investigated the protective effects of Shen-Fu injection (SFI) on a caerulein-induced rat pancreatitis (AP) model.

METHODS:

SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies.

RESULTS:

Our results showed that AP caused significant decrease in tissue glutathione (GSH) and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA) and myeloperoxidase (MPO) were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein.

CONCLUSION:

Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB) activity.

PMID:
24738018
PMCID:
PMC3964904
DOI:
10.1155/2014/248786
[Indexed for MEDLINE]
Free PMC Article

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