Format

Send to

Choose Destination
Mediators Inflamm. 2014;2014:608414. doi: 10.1155/2014/608414. Epub 2014 Mar 11.

The time profile of Pentraxin 3 in patients with acute ST-elevation myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention.

Author information

1
Department of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway ; Faculty of Medicine, University of Oslo, P.O. Box 1078, Blindern, 0316 Oslo, Norway.
2
Department of Cardiology, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway.
3
Section for Interventional Cardiology, Department of Cardiology, Division of Cardiovascular and Pulmonary Diseases, Oslo University Hospital Ullevål, P.O. Box 4956, Nydalen, 0424 Oslo, Norway.

Abstract

BACKGROUND:

High levels of Pentraxin 3 (PTX3) are reported in acute myocardial infarction (AMI).

AIM:

To investigate circulating levels and gene expression of PTX3 in patients with AMI and stable angina pectoris (AP) undergoing PCI.

METHODS:

Ten patients with AP and 20 patients with AMI were included. Blood samples were drawn before PCI in the AP group and after 3 and 12 hours and days 1, 3, 5, 7, and 14 in both groups.

RESULTS:

Circulating PTX3 levels were higher in AMI compared to AP at 3 and 12 hours (P < 0.001 and P = 0.003). Within the AMI group, reduction from 3 hours to all later time points was observed (all P ≤ 0.001). Within the AP group, increase from baseline to 3 hours (P = 0.022), followed by reductions thereafter (all P < 0.05), was observed. PTX3 mRNA increased in the AMI group from 3 hours to days 7 and 14 in a relative manner of 62% and 73%, while a relative reduction from baseline to 3 and 12 hours of 29% and 37% was seen in the AP group.

CONCLUSION:

High circulating PTX3 levels shortly after PCI in AMI indicate that AMI itself influences PTX3 levels. PTX3 mRNA might be in response to fluctuations in circulating levels.

PMID:
24737925
PMCID:
PMC3967811
DOI:
10.1155/2014/608414
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central Icon for Norwegian BIBSYS system
Loading ...
Support Center