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Appl Phys Lett. 2014 Mar 24;104(12):123702. Epub 2014 Mar 27.

Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer.

Author information

1
Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA ; Department of Chemical Engineering and Materials Science, University of California, Irvine, Irvine, California 92697, USA.
2
Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA.
3
Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, California 90089, USA.
4
Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road East, Irvine, California 92612, USA ; Department of Chemical Engineering and Materials Science, University of California, Irvine, Irvine, California 92697, USA ; Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697, USA.

Abstract

We designed and developed a confocal acoustic radiation force optical coherence elastography system. A ring ultrasound transducer was used to achieve reflection mode excitation and generate an oscillating acoustic radiation force in order to generate displacements within the tissue, which were detected using the phase-resolved optical coherence elastography method. Both phantom and human tissue tests indicate that this system is able to sense the stiffness difference of samples and quantitatively map the elastic property of materials. Our confocal setup promises a great potential for point by point elastic imaging in vivo and differentiation of diseased tissues from normal tissue.

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