Send to

Choose Destination
See comment in PubMed Commons below
J Comp Neurol. 2014 Aug 15;522(12):2831-44. doi: 10.1002/cne.23608. Epub 2014 May 7.

Self-organization of neural tissue architectures from pluripotent stem cells.

Author information

Institute of Reconstructive Neurobiology, University of Bonn LIFE&BRAIN Center, and LIFE&BRAIN GmbH, 53127, Bonn, Germany.


Despite being a subject of intensive research, the mechanisms underlying the formation of neural tissue architectures during development of the central nervous system remain largely enigmatic. So far, studies into neural pattern formation have been restricted mainly to animal experiments. With the advent of pluripotent stem cells it has become possible to explore early steps of nervous system development in vitro. These studies have unraveled a remarkable propensity of primitive neural cells to self-organize into primitive patterns such as neural tube-like rosettes in vitro. Data from more advanced 3D culture systems indicate that this intrinsic propensity for self-organization can even extend to the formation of complex architectures such as a multilayered cortical neuroepithelium or an entire optic cup. These novel experimental paradigms not only demonstrate the enormous self-organization capacity of neural stem cells, they also provide exciting prospects for studying the earliest steps of human neural tissue development and the pathogenesis of brain malformations in reductionist in vitro paradigms.


3D culture; cortical development; neural stem cell; rosette formation

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center