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J Clin Immunol. 2014 Jul;34(5):544-7. doi: 10.1007/s10875-014-0036-1. Epub 2014 Apr 16.

Secondary hemophagocytic lymphohistiocytosis (HLH) from a presumed brown recluse spider bite.

Author information

1
Department of Pediatrics, Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7015, 45229, Cincinnati, OH, USA, christopher.dandoy@cchmc.org.

Abstract

Systemic loxoscelism is a rare complication after Loxosceles reclusa (brown recluse spider) envenomation. Loxosceles venom contains pro-inflammatory proteins, which have been shown to be elevated in patients with hemophagocytic lymph histiocytosis. We present a case of a 10-year-old male that developed presumed systemic loxoscelism, secondary hemophagocytic lymphohistiocytosis with hepatic dysfunction and renal failure. He was treated with dexamethasone and made a full recovery.

PMID:
24737162
DOI:
10.1007/s10875-014-0036-1
[Indexed for MEDLINE]
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