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PLoS One. 2014 Apr 15;9(4):e94844. doi: 10.1371/journal.pone.0094844. eCollection 2014.

Task-specific and general cognitive effects in Chiari malformation type I.

Author information

1
Department of Psychology, University of Akron, Akron, Ohio, United States of America; Conquer Chiari Research Center, University of Akron, Akron, Ohio, United States of America.
2
Department of Psychology, University of Akron, Akron, Ohio, United States of America.
3
Conquer Chiari Research Center, University of Akron, Akron, Ohio, United States of America; Department of Mechanical Engineering, University of Akron, Akron, Ohio, United States of America.
4
School of Psychological Science, Oregon State University, Corvallis, Oregon, United States of America.
5
Neurological Center for Pain, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America.
6
Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America.

Abstract

OBJECTIVE:

Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction.

BACKGROUND:

CM is a neurological syndrome in which the cerebellum descends into the cervical spine causing neural compression, severe headaches, neck pain, and number of other physical symptoms. While primarily a disorder of the cervico-medullary junction, both clinicians and researchers have suspected deficits in higher-level cognitive function.

DESIGN AND METHODS:

We tested 24 CM patients who had undergone decompression neurosurgery and 24 age- and education-matched controls on measures of immediate and delayed episodic memory, as well as three measures of executive function.

RESULTS:

The CM group showed performance decrements relative to the controls in response inhibition (Stroop interference), working memory computational speed (Ospan), and processing speed (automated digit symbol substitution task), but group differences in recall did not reach statistical significance. After statistical control for depression and anxiety scores, the group effects for working memory and processing speed were eliminated, but not for response inhibition. This response inhibition difference was not due to overall general slowing for the CM group, either, because when controls' data were transformed using the linear function fit to all of the reaction time tasks, the interaction with group remained statistically significant. Furthermore, there was a multivariate group effect for all of the response time measures and immediate and delayed recall after statistical control of depression and anxiety scores.

CONCLUSION:

These results suggest that CM patients with decompression surgery exhibit cognitive dysfunction compared to age- and education-matched controls. While some of these results may be related to anxiety and depression (likely proxies for chronic pain), response inhibition effects, in particular, as well as a general cognitive deficit persisted even after control for anxiety and decompression.

PMID:
24736676
PMCID:
PMC3988081
DOI:
10.1371/journal.pone.0094844
[Indexed for MEDLINE]
Free PMC Article

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