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PLoS Med. 2014 Apr 15;11(4):e1001627. doi: 10.1371/journal.pmed.1001627. eCollection 2014.

A physicians' wish list for the clinical application of intestinal metagenomics.

Author information

1
Core Facility Molecular Biology, Center for Medical Research, Medical University of Graz, Graz, Austria.
2
Department of Gastroenterology and Hepatology, Medical University of Graz, Graz, Austria.
3
Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria; Core Facility Bioinformatics, Austrian Centre of Industrial Biotechnology, Graz, Austria.
4
Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
5
Division of Infectious Diseases, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Abstract

Christoph Steininger and colleagues explore how multiple infectious, autoimmune, metabolic, and neoplastic diseases have been associated with changes in the intestinal microbiome, although a cause-effect relationship is often difficult to establish. Integration of metagenomics into clinical medicine is a challenge, and the authors highlight clinical approaches that are of high priority for the useful medical application of metagenomics. Please see later in the article for the Editors' Summary.

PMID:
24736271
PMCID:
PMC3987993
DOI:
10.1371/journal.pmed.1001627
[Indexed for MEDLINE]
Free PMC Article
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