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Neuroimage. 2014 Aug 15;97:117-26. doi: 10.1016/j.neuroimage.2014.04.009. Epub 2014 Apr 13.

Thalamus and posterior temporal lobe show greater inter-network connectivity at rest and across sensory paradigms in schizophrenia.

Author information

1
Computer Science Department, University of New Mexico, Albuquerque, NM 87131, United States. Electronic address: musicet37@gmail.com.
2
Mathematics Department, University of New Mexico, Albuquerque, NM 87131, United States.
3
Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
4
The Mind Research Network, Albuquerque, NM 87106, United States.
5
The Mind Research Network, Albuquerque, NM 87106, United States; Psychology Department, University of New Mexico, Albuquerque, NM 87131, United States; Neurology Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
6
Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States; Psychiatry Research Program, New Mexico VA Health Care System, Albuquerque, NM 87108, United States; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
7
Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
8
Departments of Psychiatry & Neurobiology, Yale University, New Haven, CT 06511, United States.
9
Psychiatry Department, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States; The Mind Research Network, Albuquerque, NM 87106, United States; Electrical and Computer Engineering Department, University of New Mexico, Albuquerque, NM 87131, United States.

Abstract

Although a number of recent studies have examined functional connectivity at rest, few have assessed differences between connectivity both during rest and across active task paradigms. Therefore, the question of whether cortical connectivity patterns remain stable or change with task engagement continues to be unaddressed. We collected multi-scan fMRI data on healthy controls (N=53) and schizophrenia patients (N=42) during rest and across paradigms arranged hierarchically by sensory load. We measured functional network connectivity among 45 non-artifactual distinct brain networks. Then, we applied a novel analysis to assess cross paradigm connectivity patterns applied to healthy controls and patients with schizophrenia. To detect these patterns, we fit a group by task full factorial ANOVA model to the group average functional network connectivity values. Our approach identified both stable (static effects) and state-based differences (dynamic effects) in brain connectivity providing a better understanding of how individuals' reactions to simple sensory stimuli are conditioned by the context within which they are presented. Our findings suggest that not all group differences observed during rest are detectable in other cognitive states. In addition, the stable differences of heightened connectivity between multiple brain areas with thalamus across tasks underscore the importance of the thalamus as a gateway to sensory input and provide new insight into schizophrenia.

KEYWORDS:

Connectivity; Posterior temporal areas; Schizophrenia; Static & dynamic connectivity; Thalamus; fMRI

PMID:
24736181
PMCID:
PMC4087193
DOI:
10.1016/j.neuroimage.2014.04.009
[Indexed for MEDLINE]
Free PMC Article

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