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Invest Ophthalmol Vis Sci. 2014 Apr 15;55(5):3067-73. doi: 10.1167/iovs.13-13657.

Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys.

Author information

1
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
2
Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
3
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
4
Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany.
5
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
6
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China.
7
Department of Ophthalmology, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
8
Hamilton Glaucoma Center and Department of Ophthalmology, University of California-San Diego, La Jolla, California, United States.

Abstract

PURPOSE:

To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head.

METHODS:

This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (CSF) shunt. In the study group (n = 4 monkeys), the shunt was opened to achieve a CSF of approximately 40 mm H2O, while the shunt remained closed in the control group (n = 5 monkeys). At baseline and in monthly intervals thereafter, optical coherence tomographic and photographic images of the optic nerve head and RNFL were taken of all monkeys.

RESULTS:

Two out of four monkeys in the study group showed bilaterally a progressive reduction in RNFL thickness between 12% and 30%, reduction in neuroretinal rim area and volume, and increase in cup-to-disc area ratios. A third monkey developed a splinter-like disc hemorrhage in one eye. The fourth monkey in the study group did not develop morphologic changes during follow-up, nor did any monkey in the control group.

CONCLUSIONS:

Experimental and chronic reduction in CSF in monkeys was associated with the development of an optic neuropathy in some monkeys.

KEYWORDS:

cerebrospinal fluid pressure; glaucoma; glaucomatous optic neuropathy; intraocular pressure; normal-pressure glaucoma; trans-lamina cribrosa pressure difference

PMID:
24736050
DOI:
10.1167/iovs.13-13657
[Indexed for MEDLINE]
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