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Front Neuroendocrinol. 2014 Oct;35(4):473-93. doi: 10.1016/j.yfrne.2014.04.001. Epub 2014 Apr 13.

Neural innervation of white adipose tissue and the control of lipolysis.

Author information

1
Department of Biology, Center for Obesity Reversal, Georgia State University, Atlanta, GA 30302-4010, USA; Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302-4010, USA. Electronic address: bartness@gsu.edu.
2
Department of Biology, Center for Obesity Reversal, Georgia State University, Atlanta, GA 30302-4010, USA; Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302-4010, USA; Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
3
Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-executed SNS-norepinephrine (NE)-mediated WAT lipolysis is dependent on β-adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A phosphorylation. WAT sympathetic drive is appropriately measured electrophysiologically and neurochemically (NE turnover) in non-human animals and this drive is fat pad-specific preventing generalizations among WAT depots and non-WAT organs. Leptin-triggered SNS-mediated lipolysis is weakly supported, whereas insulin or adenosine inhibition of SNS/NE-mediated lipolysis is strongly supported. In addition to lipolysis control, increases or decreases in WAT SNS drive/NE inhibit and stimulate white adipocyte proliferation, respectively. WAT sensory nerves are of spinal-origin and sensitive to local leptin and increases in sympathetic drive, the latter implicating lipolysis. Transsynaptic viral tract tracers revealed WAT central sympathetic and sensory circuits including SNS-sensory feedback loops that may control lipolysis.

KEYWORDS:

Denervation; Herpes simplex virus-1; Humans; Insulin; Leptin; Mice; Norepinephrine turnover; Pseudorabies virus; Rats; Siberian hamsters

PMID:
24736043
PMCID:
PMC4175185
DOI:
10.1016/j.yfrne.2014.04.001
[Indexed for MEDLINE]
Free PMC Article

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