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Stem Cell Res. 2014 May;12(3):754-61. doi: 10.1016/j.scr.2014.03.007. Epub 2014 Apr 1.

Phases of reprogramming.

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INSERM, UMR 1064, Nantes, France; Faculté de Médecine, Université de Nantes, France; iPSC Facility, SFR F. Bonamy, Université de Nantes, France. Electronic address:
Department of Anatomy and Developmental Biology, Monash University, Australia; Australian Regenerative Medicine Institute, Monash University, Australia. Electronic address:


Despite advances in the field of somatic cell reprogramming, an understanding and exploration of the underlying mechanisms governing this process are only recently emerging. It is now increasingly apparent that key sequential events correlate with the reprogramming process; a process previously thought to be random and unpredictable is now looking, to a greater extent, defined and controlled. Herein, we will review the key cellular and molecular events associated with the reprogramming process, giving an integrative and conciliatory view of the different studies addressing the mechanism of nuclear reprogramming.

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