Send to

Choose Destination
See comment in PubMed Commons below
Spine J. 2014 Oct 1;14(10):2472-8. doi: 10.1016/j.spinee.2014.04.001. Epub 2014 Apr 13.

Dorsal root ganglion electrical stimulation promoted intertransverse process spinal fusion without decortications and bone grafting: a proof-of-concept study.

Author information

  • 1Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong.
  • 2Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong.
  • 3School of Aerospace, Tsinghua University, China.
  • 4Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong. Electronic address:



Periosteum, endosteum, and bone are innervated by sensory nerves expressing calcitonin gene-related peptide (CGRP), which is a known osteoanabolic peptide and plays an important role in fracture healing and spinal fusion. Synthesis and release of CGRP are found in sensory neurons located in the dorsal root ganglions (DRGs) and can be upregulated by electrical stimulation (ES) at DRG.


To prove our study hypothesis on the potential of precise ES at DRG through implantable microelectrical stimulation system (IMESS) for its effect on promoting spinal fusion in a rat model without decortications and bone grafting.


An experimental animal study.


A novel IMESS was developed for stimulating L4-L6 DRG in rats. Sixteen rats were used and divided equally into the control group without ES and the ES group, with a daily 20 minutes ES to DRG for 6 weeks. At the end of 6 weeks, radiography and microcomputed tomography were conducted to evaluate new bone formation and spinal fusion. Bilateral L4-L6 DRGs were harvested for immunohistochemistry and quantification of neurons with upregulated CGRP expression.


In the ES group, rate of radiographic fusion with complete and uninterrupted bony bridging was 100% (8/8) at the right L4/L5 transverse processes and 75% (6/8) at the right L5/L6 transverse processes. Bony callus formation was absent at the left L4-L6 transverse processes in the ES group and in bilateral L4-L6 transverse processes in the control group.


We proved for the first time that precise ES at DRG through IMESS effectively promoted intertransverse process fusion in rat model without decortications and bone grafting. Electrical stimulation at DRG might be an attractive minimal invasive bioengineering approach and an alternative therapy for intertransverse process fusion that is increasingly being used for the treatment of degenerative spine disorders.


Animal model; Calcitonin gene-related peptide; Dorsal root ganglion stimulation; Implantable microelectrical stimulation system; Minimally invasive; Spinal fusion

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center