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Int J Pediatr Otorhinolaryngol. 2014 Jun;78(6):960-3. doi: 10.1016/j.ijporl.2014.03.025. Epub 2014 Mar 30.

Effect of topical dexamethasone in reducing dysfunction after facial nerve crush injury in the rat.

Author information

1
Department of Otolaryngology, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: chulsavio@hanmail.net.
2
Department of Otolaryngology, Chonnam National University Medical School, Gwangju, South Korea.
3
Department of Bio New Drug Development, Chosun University, Gwangju, South Korea.
4
Department of Biomedical Enginnering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Pusan, South Korea.

Abstract

OBJECTIVE:

To date, the effect of topical steroid after a crush injury to rat facial nerve has rarely been reported on. The aim of this study was to investigate the effects of topical dexamethasone on recovery after a crush injury to the rat facial nerve, by functional, electrophysiological, and morphological evaluation.

MATERIALS AND METHODS:

We investigated the effects of topical dexamethasone on recovery after a crush injury to rat facial nerve by functional, electrophysiological and morphological evaluation.

RESULTS:

The functional recovery using vibrissae movement was significantly high scores in the experimental group than control group at two and three weeks post-crush. The recovery of the threshold of muscle action potential was significantly lowered in the experimental group compared to the control (p<0.05). However, there was no statistical significance in the nerve conduction velocity. The dexamethasone treatment groups showed a larger axon diameter and thicker myelin sheath than the control group.

CONCLUSION:

From our results, topical dexamethasone accelerates recovery of the crush-injured facial nerve.

KEYWORDS:

Dexamethasone; Facial nerve crush; Topical

PMID:
24735605
DOI:
10.1016/j.ijporl.2014.03.025
[Indexed for MEDLINE]
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