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J Ophthalmol. 2014;2014:265012. doi: 10.1155/2014/265012. Epub 2014 Mar 5.

Corneal backscatter analysis by in vivo confocal microscopy: fellow eye comparison of small incision lenticule extraction and femtosecond laser-assisted LASIK.

Author information

1
Beyoglu Eye Research and Training Hospital, 34421 Istanbul, Turkey.
2
Department of Ophthalmology, Istanbul Medeniyet University, 34730 Istanbul, Turkey.

Abstract

PURPOSE:

To evaluate and compare corneal backscatter from anterior stroma between small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (femto-LASIK).

METHODS:

A cohort of 60 eyes of 30 patients was randomized to receive SMILE in one eye and femto-LASIK in the fellow eye. In vivo confocal microscopy was performed at 1 week and 1, 3, and 6 months after surgery. The main outcome measurements were maximum backscattered intensity and the depth from which it was measured, the backscattered light intensity 30  μ m below Bowman's membrane at the flap interface and 150  μ m below the superficial epithelium, and the number of refractive particles at the flap interface.

RESULTS:

The mean backscattered light intensity (LI) at all measured depths and the maximum backscattered LI were higher in the SMILE group than the femto-LASIK group at all postoperative visits. LI differences at 1 week and 1- and 3-month visits were statistically significant (P < 0,05). LI differences at 6 months were not statistically significant. There was no difference in the number of refractive particles at the flap interface between the groups at any visit.

CONCLUSIONS:

SMILE results in increased backscattered LI in the anterior stroma when compared with femto-LASIK were evaluated.

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