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Front Syst Neurosci. 2014 Mar 28;8:41. doi: 10.3389/fnsys.2014.00041. eCollection 2014.

Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse.

Author information

1
Department of Cell Biology and Anatomy, University of Calgary Calgary, AB, Canada ; Hotchkiss Brain Institute, University of Calgary Calgary, AB, Canada ; Genes and Development Research Group, Faculty of Medicine, University of Calgary Calgary, AB, Canada.

Abstract

The cerebellar cortex comprises a stereotyped array of transverse zones and parasagittal stripes, built around multiple Purkinje cell subtypes, which is highly conserved across birds and mammals. This architecture is revealed in the restricted expression patterns of numerous molecules, in the terminal fields of the afferent projections, in the distribution of interneurons, and in the functional organization. This review provides an overview of cerebellar architecture with an emphasis on attempts to relate molecular architecture to the expression of long-term depression (LTD) at the parallel fiber-Purkinje cell (pf-PC) synapse.

KEYWORDS:

Purkinje cell; long-term depression; phospholipase Cβ4; stripes; zebrin II

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