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JAMA Neurol. 2014 Apr;71(4):495-8. doi: 10.1001/jamaneurol.2013.6331.

Paraneoplastic neuromyelitis optica spectrum disorder associated with metastatic carcinoid expressing aquaporin-4.

Author information

1
Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan.
2
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.
3
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota3Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota4Department of Pathology and Immunology, Mayo Clinic College of Medicine, Rochester, Min.
4
Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan5Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan.

Abstract

IMPORTANCE:

Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis.

OBSERVATIONS:

In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department at Wayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation.

CONCLUSIONS AND RELEVANCE:

This case extends the context of NMOSD as a paraneoplastic disorder.

PMID:
24733266
PMCID:
PMC4076888
DOI:
10.1001/jamaneurol.2013.6331
[Indexed for MEDLINE]
Free PMC Article

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