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PLoS One. 2014 Apr 14;9(4):e94729. doi: 10.1371/journal.pone.0094729. eCollection 2014.

Drosophila microbiota modulates host metabolic gene expression via IMD/NF-κB signaling.

Author information

1
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon-1, Lyon, France; Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut de Biologie du Développement de Marseille-Luminy, Marseille, France.
2
Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut de Biologie du Développement de Marseille-Luminy, Marseille, France.
3
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon-1, Lyon, France.
4
Technological Advances for Genomics and Clinics, Institut National de la Santé et de la Recherche Médicale, Aix-Marseille Université, Marseille, France.

Erratum in

  • PLoS One. 2014 Jul;9(7):e104120. Erkosar Combe, Berra [corrected to Erkosar, Berra].

Abstract

Most metazoans engage in mutualistic interactions with their intestinal microbiota. Despite recent progress the molecular mechanisms through which microbiota exerts its beneficial influences on host physiology are still largely uncharacterized. Here we use axenic Drosophila melanogaster adults associated with a standardized microbiota composed of a defined set of commensal bacterial strains to study the impact of microbiota association on its host transcriptome. Our results demonstrate that Drosophila microbiota has a marked impact on the midgut transcriptome and promotes the expression of genes involved in host digestive functions and primary metabolism. We identify the IMD/Relish signaling pathway as a central regulator of this microbiota-mediated transcriptional response and we reveal a marked transcriptional trade-off between the midgut response to its beneficial microbiota and to bacterial pathogens. Taken together our results indicate that microbiota association potentiates host nutrition and host metabolic state, two key physiological parameters influencing host fitness. Our work paves the way to subsequent mechanistic studies to reveal how these microbiota-dependent transcriptional signatures translate into host physiological benefits.

PMID:
24733183
PMCID:
PMC3986221
DOI:
10.1371/journal.pone.0094729
[Indexed for MEDLINE]
Free PMC Article

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