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Chem Commun (Camb). 2014 May 30;50(42):5644-7. doi: 10.1039/c4cc01907e.

In situ generation of sulfoxides with predetermined chirality via a structural template with a chiral-at-metal ruthenium complex.

Author information

1
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. cesybh@mail.sysu.edu.cn.

Abstract

The reaction of Δ/Λ-[Ru(bpy)2(py)2](2+) with a prochiral sulfide ligand, and then in situ oxidation, provide the corresponding Δ-[Ru(bpy)2{(R)-OSO-iPr}](+) and Λ-[Ru(bpy)2{(S)-OSO-iPr}](+) (OSO-iPr = 2-isopropylsulfonylbenzonate) enantiomers in a yield of 83% with 98% ee. The chiral sulfoxides were obtained by treatment of the sulfoxide complexes with TFA in a yield of 90% with 88-91% ee.

PMID:
24733168
DOI:
10.1039/c4cc01907e
[Indexed for MEDLINE]

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