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Pediatr Res. 2014 Jul;76(1):100-8. doi: 10.1038/pr.2014.48. Epub 2014 Apr 14.

Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants.

Author information

1
1] Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama [2] Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.
2
1] Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama [2] Department of Pediatrics, Oregon Health and Science University, Portland, Oregon.
3
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
4
Statistics and Epidemiology Unit, RTI International, Research Triangle Park, North Carolina.
5
Department of Obstetrics and Gynecology, Lillebaelt Hospital, Kolding, Denmark.
6
Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
7
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Abstract

BACKGROUND:

The goal was to identify cytokines associated with necrotizing enterocolitis (NEC). Based on our earlier reports of decreased tissue expression of transforming growth factor (TGF)-β, we hypothesized that infants with NEC also have low blood TGF-β levels. We further hypothesized that because fetal inflammation increases the risk of NEC, infants who develop NEC have elevated blood cytokine levels in early neonatal period.

METHODS:

Data on 104 extremely-low-birth-weight infants with NEC and 893 without NEC from 17 centers were analyzed. Clinical information was correlated with blood cytokine levels on postnatal day 1 (D1), D3, D7, D14, and D21.

RESULTS:

Male gender, non-Caucasian/non-African American ethnicity, sepsis, lower blood TGF-β and interleukin (IL)-2 levels, and higher IL-8 levels were associated with NEC. The NEC group had lower TGF-β levels than controls since D1. The diagnosis of NEC was associated with elevated IL-1β, IL-6, IL-8, IL-10, monocyte chemoattractant protein-1/CC-motif ligand-2, macrophage inflammatory protein-1β/CC-motif ligand-3, and C-reactive protein.

CONCLUSION:

Clinical characteristics, such as gender and ethnicity, and low blood TGF-β levels are associated with higher risk of NEC. Infants who developed NEC did not start with high blood levels of inflammatory cytokines, but these rose mainly after the onset of NEC.

PMID:
24732104
PMCID:
PMC4062583
DOI:
10.1038/pr.2014.48
[Indexed for MEDLINE]
Free PMC Article

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