Format

Send to

Choose Destination
Lupus. 2014 Sep;23(10):1054-8. doi: 10.1177/0961203314532563. Epub 2014 Apr 14.

Sleep disorders in systemic lupus erythematosus. Does vitamin D play a role?

Author information

1
Poursina Hakim Research Institution, Isfahan, Iran gholamrezaei@med.mui.ac.ir.
2
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
3
Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

OBJECTIVES:

Sleep disorders are common among patients with systemic lupus erythematosus (SLE) with unclear underlying mechanisms. We assessed the role of vitamin D in sleep quality of patients with SLE.

METHODS:

A retrospective study was conducted on women with SLE for whom the following data were available at the same time; sleep quality (Pittsburgh Sleep Quality Index (PSQI)), disease activity, cumulative disease damage, psychological state (Hospital Anxiety and Depression Scale (HADS)), and serum vitamin D level. Bivariate and regression analyses were computed to find contributors of sleep quality.

RESULTS:

In total, 63 women were studied. Serum vitamin D level was correlated with physical activity (r=0.310, p=0.015), season of assessment (r=-0.302, p=0.016), the PSQI global score (r=-0.262, p=0.043), anxiety score (r=-0.298, p=0.021), and non-significantly with depression score (r=-0.218, p=0.094). Including all variables into a linear regression model, vitamin D level was independently associated with the global PSQI score (beta=-0.364, p=0.042). Association of vitamin D level with psychological state disappeared after controlling for season of assessment (beta=-0.248, p=0.154).

CONCLUSIONS:

We found a role for vitamin D in sleep quality of SLE patients. Further studies are warranted to confirm these results and to find possible mechanisms of action.

KEYWORDS:

Systemic lupus erythematosus; sleep; sleep disorders; vitamin D deficiency

PMID:
24731962
DOI:
10.1177/0961203314532563
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center