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Biochim Biophys Acta. 2014 Oct;1839(10):974-977. doi: 10.1016/j.bbagrm.2014.04.002. Epub 2014 Apr 13.

Riboswitches in regulation of Rho-dependent transcription termination.

Author information

1
Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow 119991, Russia; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow 117545, Russia.
2
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address: evgeny.nudler@nyumc.org.

Abstract

Riboswitches are RNA sensors of small metabolites and ions that regulate gene expression in response to environmental changes. In bacteria, the riboswitch sensor domain usually controls the formation of a strong RNA hairpin that either functions as a potent transcription terminator or sequesters a ribosome-binding site. A recent study demonstrated a novel mechanism by which a riboswitch controls Rho-dependent transcription termination. This riboswitch mechanism is likely a widespread mode of gene regulation that determines whether a protein effector is able to attenuate transcription. This article is part of a Special Issue entitled: Riboswitches.

KEYWORDS:

Rho; Riboswitch; Transcription termination

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