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Diagn Microbiol Infect Dis. 2014 Jun;79(2):252-4. doi: 10.1016/j.diagmicrobio.2014.03.010. Epub 2014 Mar 18.

Evaluation of avibactam-supplemented combination disk tests for the detection of OXA-48 carbapenemase-producing Enterobacteriaceae.

Author information

1
National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-negative bacteria, CHU Dinant-Godinne|UCL Namur, 1 Avenue Dr. G. Therasse, 5530 Yvoir, Belgium. Electronic address: te-din.huang@uclouvain.be.
2
National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-negative bacteria, CHU Dinant-Godinne|UCL Namur, 1 Avenue Dr. G. Therasse, 5530 Yvoir, Belgium.

Abstract

The ability of various combination disk tests (CDTs) incorporating avibactam to detect OXA-48 carbapenemase-producing Enterobacteriaceae was evaluated. The CDT using 30-μg temocillin alone and supplemented with 5-μg avibactam showed good performance and could be an adjunctive test to the classic CDT containing class A and class B carbapenemase inhibitors for the positive discrimination of OXA-48 carbapenemase producers from carbapenemase-negative strains.

KEYWORDS:

Inhibitor; OXA-type beta-lactamase; Temocillin

[Indexed for MEDLINE]

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