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Trends Endocrinol Metab. 2014 Oct;25(10):502-8. doi: 10.1016/j.tem.2014.03.004. Epub 2014 Apr 12.

Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy.

Author information

1
Program in Systems Biology, Program in Molecular Medicine, University of Massachusetts Medical School, 55 North Lake Ave, Worcester, MA, 01655, USA.
2
Program in Systems Biology, Program in Molecular Medicine, University of Massachusetts Medical School, 55 North Lake Ave, Worcester, MA, 01655, USA. Electronic address: marian.walhout@umassmed.edu.

Abstract

Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control of metabolic enzymes. Here, we discuss recent insights regarding metazoan metabolic regulatory networks using the nematode Caenorhabditis elegans as a model, including the modular organization of metabolic gene regulatory networks, the prominent impact of diet on the transcriptome and metabolome, specialized roles of nuclear hormone receptors (NHRs) in responding to dietary conditions, regulation of metabolic genes and metabolic regulators by miRNAs, and feedback between metabolic genes and their regulators.

KEYWORDS:

C. elegans; bacteria; gene expression; gene regulatory network; life history traits; metabolic network; nuclear hormone receptors; nutrient response; transcription

PMID:
24731597
PMCID:
PMC4178166
DOI:
10.1016/j.tem.2014.03.004
[Indexed for MEDLINE]
Free PMC Article

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