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Food Chem. 2014 Sep 1;158:340-4. doi: 10.1016/j.foodchem.2014.02.094. Epub 2014 Mar 5.

ZnCl2-mediated practical protocol for the synthesis of Amadori ketoses.

Author information

1
Food Safety and Analytical Quality Control Laboratory, CSIR-CFTRI, KRS Road, Mysore 570020, Karnataka, India. Electronic address: nani.shankar@gmail.com.
2
Food Safety and Analytical Quality Control Laboratory, CSIR-CFTRI, KRS Road, Mysore 570020, Karnataka, India.

Abstract

An efficient and practical protocol for the synthesis of Amadori ketoses N-(1-deoxy-D-fructose-1-yl) amino acid (amino acid=L-valine (1), L-leucine (2), L-isoleucine (3), L-tryptophan (4), L-phenylalanine (5), L-arginine (6) has been accomplished by employing ZnCl2 as a catalyst. The developed method circumvents protection and deprotection steps as well as tedious ion-exchange and column chromatographic techniques. The accomplished Amadori ketoses showed moderate to weak angiotensin I converting enzyme (ACE) inhibitory activity.

KEYWORDS:

ACE; Amadori rearrangement; Zinc

PMID:
24731352
DOI:
10.1016/j.foodchem.2014.02.094
[Indexed for MEDLINE]
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