Format

Send to

Choose Destination
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W264-70. doi: 10.1093/nar/gku270. Epub 2014 Apr 11.

The DynaMine webserver: predicting protein dynamics from sequence.

Author information

1
MLG, Computer Science Department, Université Libre de Bruxelles (ULB), Brussels, Belgium Interuniversity Institute of Bioinformatics in Brussels (IB), ULB-VUB, Brussels, Belgium ecilia@ulb.ac.be.
2
Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium Department of Structural Biology, VIB, Brussels, Belgium.
3
Interuniversity Institute of Bioinformatics in Brussels (IB), ULB-VUB, Brussels, Belgium Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium Department of Structural Biology, VIB, Brussels, Belgium Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.
4
MLG, Computer Science Department, Université Libre de Bruxelles (ULB), Brussels, Belgium Interuniversity Institute of Bioinformatics in Brussels (IB), ULB-VUB, Brussels, Belgium AI-Lab, Computer Science Department, Vrije Universiteit Brussel, Brussels, Belgium.
5
Interuniversity Institute of Bioinformatics in Brussels (IB), ULB-VUB, Brussels, Belgium Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium Department of Structural Biology, VIB, Brussels, Belgium.

Abstract

Protein dynamics are important for understanding protein function. Unfortunately, accurate protein dynamics information is difficult to obtain: here we present the DynaMine webserver, which provides predictions for the fast backbone movements of proteins directly from their amino-acid sequence. DynaMine rapidly produces a profile describing the statistical potential for such movements at residue-level resolution. The predicted values have meaning on an absolute scale and go beyond the traditional binary classification of residues as ordered or disordered, thus allowing for direct dynamics comparisons between protein regions. Through this webserver, we provide molecular biologists with an efficient and easy to use tool for predicting the dynamical characteristics of any protein of interest, even in the absence of experimental observations. The prediction results are visualized and can be directly downloaded. The DynaMine webserver, including instructive examples describing the meaning of the profiles, is available at http://dynamine.ibsquare.be.

PMID:
24728994
PMCID:
PMC4086073
DOI:
10.1093/nar/gku270
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center