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PLoS One. 2014 Apr 11;9(4):e93515. doi: 10.1371/journal.pone.0093515. eCollection 2014.

Thyroid function and body weight: a community-based longitudinal study.

Author information

1
Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.
2
Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Faculty of Health Sciences, Copenhagen, Denmark; Faculty of Medicine, Aalborg University, Aalborg, Denmark.
3
Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.
4
Faculty of Medicine, Aalborg University, Aalborg, Denmark; Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
5
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
6
Department of Gastroenterology, Slagelse Hospital, Slagelse, Denmark.
7
Department of Nutrition, National Food Institute, Technical University of Denmark, Søborg, Denmark.

Abstract

OBJECTIVE:

Body weight and overt thyroid dysfunction are associated. Cross-sectional population-based studies have repeatedly found that thyroid hormone levels, even within the normal reference range, might be associated with body weight. However, for longitudinal data, the association is less clear. Thus, we tested the association between serum thyrotropin (TSH) and body weight in a community-based sample of adult persons followed for 11 years.

METHODS:

A random sample of 4,649 persons aged 18-65 years from a general population participated in the DanThyr study in 1997-8. We included 2,102 individuals who participated at 11-year follow-up, without current or former treatment for thyroid disease and with measurements of TSH and weight at both examinations. Multiple linear regression models were used, stratified by sex and adjusted for age, smoking status, and leisure time physical activity.

RESULTS:

Baseline TSH concentration was not associated with change in weight (women, P = 0.17; men, P = 0.72), and baseline body mass index (BMI) was not associated with change in TSH (women, P = 0.21; men, P = 0.85). Change in serum TSH and change in weight were significantly associated in both sexes. Weight increased by 0.3 kg (95% confidence interval [CI] 0.1, 0.4, P = 0.005) in women and 0.8 kg (95% CI 0.1, 1.4, P = 0.02) in men for every one unit TSH (mU/L) increase.

CONCLUSIONS:

TSH levels were not a determinant of future weight changes, and BMI was not a determinant for TSH changes, but an association between weight change and TSH change was present.

PMID:
24728291
PMCID:
PMC3984087
DOI:
10.1371/journal.pone.0093515
[Indexed for MEDLINE]
Free PMC Article

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