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Nat Neurosci. 2014 May;17(5):667-9. doi: 10.1038/nn.3695. Epub 2014 Apr 13.

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

Author information

1
Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland.
2
Gurdon Institute, Cambridge, UK.
3
Institute of Laboratory Animal Science, University of Zürich, Zürich, Switzerland.
4
1] FASTERIS SA, Plan-les-Ouates, Switzerland. [2].
5
FASTERIS SA, Plan-les-Ouates, Switzerland.

Abstract

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

PMID:
24728267
PMCID:
PMC4333222
DOI:
10.1038/nn.3695
[Indexed for MEDLINE]
Free PMC Article

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