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Trends Endocrinol Metab. 2014 Aug;25(8):375-7. doi: 10.1016/j.tem.2014.02.002. Epub 2014 Apr 11.

Beta cell imaging - a key tool in optimized diabetes prevention and treatment.

Author information

1
Radboud University Medical Center, Department of Radiology and Nuclear Medicine, PO Box 9101, 6500HB Nijmegen, The Netherlands. Electronic address: martin.gotthardt@radboudumc.nl.
2
Laboratory of Experimental Medicine and ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), CP 618, 1070 Brussels, Belgium.
3
Laboratory of Experimental Medicine and ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles (ULB), CP 618, 1070 Brussels, Belgium; Division of Endocrinology, Erasmus Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
4
Radboud University Medical Center, Department of Radiology and Nuclear Medicine, PO Box 9101, 6500HB Nijmegen, The Netherlands.

Abstract

The prevalence of diabetes is 382 million worldwide, and is expected to rise to 592 million in 2035 (http://www.idf.org/diabetesatlas); 2.5-15% of national annual healthcare budgets are related to diabetes care, potentially increasing to 40% in high-prevalence countries. Beta cell dysfunction and death are central events in diabetes pathogenesis, but the natural history of beta cell loss remains unknown. Clinical imaging of beta cells will play a pivotal role in developing strategies for optimized diabetes prevention and treatment.

KEYWORDS:

diabetes; imaging; pancreatic beta cells; pancreatic islets

PMID:
24726483
DOI:
10.1016/j.tem.2014.02.002
[Indexed for MEDLINE]

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