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Heart Lung Circ. 2014 Jun;23(6):503-10. doi: 10.1016/j.hlc.2014.01.001. Epub 2014 Mar 16.

Diagnosis, prognosis and therapeutic role of circulating miRNAs in cardiovascular diseases.

Author information

1
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China.
2
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China; Center for Vascular Biology and Inflammation, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, U.S.A.
3
Department of Obstetrics and Gynecology, Xiangya 3(rd) Hospital, Central South University, Changsha 410013, China.
4
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China. Electronic address: tianluny@163.com.
5
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. Electronic address: Junpeng@csu.edu.cn.

Abstract

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world. Although much progress has been made for cardiovascular diseases in diagnosis, treatment and prognosis during the past two decades, the clinical need for a novel diagnostic biomarker and new therapeutic interventions to decrease the cardiovascular disease incidence is ongoing. MicroRNAs (miRNAs) are endogenous, small (∼22 nucleotides), single-stranded, non-coding RNAs that regulate gene expression and are detectable in whole blood, serum, plasma, urine and other body fluids in a highly stable form. Accumulating evidence suggests that miRNAs are potential novel biomarkers with high sensitivity for early diagnosis and modern treatment for cardiovascular diseases. Altered circulating miRNAs expressions have been reported in acute myocardial infarction (AMI), acute coronary syndrome (ACS), stable coronary artery disease, heart failure, atherosclerosis, essential hypertension and stroke. In the present review, we examine more recent data regarding circulating miRNAs and their potential roles in diagnosis, prognosis and therapeutic strategies for cardiovascular diseases. In addition, we briefly present our own recent experience in detecting circulating miRNAs, and the significance of these miRNAs in AMI prognosis.

KEYWORDS:

Biomarkers; Cardiovascular disease (CVD); Circulating miRNAs; Prognosis; Treatment

PMID:
24726001
DOI:
10.1016/j.hlc.2014.01.001
[Indexed for MEDLINE]

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