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Cell. 2014 Apr 10;157(2):291-293. doi: 10.1016/j.cell.2014.03.043.

Multiplying messages LRRK beneath Parkinson disease.

Author information

1
Department of Neurology, Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA.
2
Department of Neurology, Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California, 695 Charles Young Drive South, Los Angeles, CA 90095, USA. Electronic address: mingfly@ucla.edu.

Abstract

Parkinson Disease (PD) is a progressive neurodegenerative disorder with limited therapeutic options. In this issue of Cell, Martin et al. link PD protein leucine-rich repeat kinase 2 (LRRK2) to abnormalities of translational control, a pathogenic mechanism implicated in an increasing number of CNS neurodegenerative diseases, as well as in normal aging.

PMID:
24725399
DOI:
10.1016/j.cell.2014.03.043
[Indexed for MEDLINE]
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