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Ann N Y Acad Sci. 2014 Apr;1311:57-76. doi: 10.1111/nyas.12416.

Obesity and cancer pathogenesis.

Author information

1
Departments of Medicine, Biochemistry, and Genetics, Center for Science, Health and Society, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Abstract

Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and worse prognosis for many but not all malignancies. Pathophysiologic processes that affect this association are reviewed, with a focus on the relationship between type 2 diabetes mellitus and cancer, lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effects of dietary fats and cholesterol on cancer promotion, and the mechanisms by which the intestinal microbiome affects obesity and cancer.

KEYWORDS:

cancer and obesity; cholesterol; diabetes; dietary fats; intestinal microbiome; murine models; pancreatic cancer

PMID:
24725147
PMCID:
PMC4500037
DOI:
10.1111/nyas.12416
[Indexed for MEDLINE]
Free PMC Article

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