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Acta Clin Belg. 2014 Apr;69(2):83-6. doi: 10.1179/2295333714Y.0000000010. Epub 2014 Mar 4.

Belgian recommendations on ANA, anti-dsDNA and anti-ENA antibody testing.


Autoantibodies to nuclear antigens, i.e. antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) and extractable nuclear antigens (ENA), are useful as diagnostic markers for a variety of autoimmune diseases. In March 2010, the Belgian national External Quality Assessment Scheme sent a questionnaire on ANA, anti-dsDNA and anti-ENA antibody testing designed by the Dutch EASI (European Autoimmunity Standardization Initiative) team, to all clinical laboratories performing ANA testing. Virtually all laboratories completed the questionnaire (97ยท7%, 127/130). This paper discusses the results of this questionnaire and provides valuable information on the state-of-the-art of ANA, anti-dsDNA and anti-ENA antibody testing as practiced in the Belgian laboratories. In addition, this work presents practical recommendations developed by the members of the advisory board of the scheme as a result of the outcome of this study.


Anti-ENA antibodies,; Anti-dsDNA antibodies,; Antinuclear antibodies,; External quality assessment; Recommendations,

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