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J Infect Dis. 2014 Oct 1;210(7):1110-4. doi: 10.1093/infdis/jiu216. Epub 2014 Apr 9.

Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi.

Author information

1
Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore Department of Medicine, University of Minnesota, Minneapolis.
2
Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore.
3
Malaria Alert Center.
4
Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
5
Department of Pharmacology, University of Malawi College of Medicine, Blantyre.

Abstract

BACKGROUND:

The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in several studies.

METHODS:

To characterize chloroquine susceptibility over a wide geographic area, infants and children aged 6-59 months were selected using 2-stage cluster sampling in 8 Malawian districts. Pyrosequencing of the pfcrt gene codon 76 region was performed for children with asexual parasitemia.

RESULTS:

Of 7145 children, 1150 had microscopic asexual parasitemia, and sequencing was performed in 685, of whom 1 had a chloroquine-resistant genotype.

CONCLUSIONS:

Systematic countrywide sampling demonstrates that the chloroquine pfcrt genotype has reached near-fixation, raising the possibility of reintroducing chloroquine for malaria prevention and treatment.

KEYWORDS:

Africa; Malawi; PfCRT; Plasmodium falciparum; chloroquine; malaria; resistance

PMID:
24723474
PMCID:
PMC6281358
DOI:
10.1093/infdis/jiu216
[Indexed for MEDLINE]
Free PMC Article

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