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Curr Protoc Neurosci. 2014 Apr 10;67:9.47.1-11. doi: 10.1002/0471142301.ns0947s67.

Rodent model of activity-based anorexia.

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1
Unidade Venres Clinicos, Universidad de Santiago de Compostela, Galicia, Spain.

Abstract

Activity-based anorexia (ABA) consists of a procedure that involves the simultaneous exposure of animals to a restricted feeding schedule, while free access is allowed to an activity wheel. Under these conditions, animals show a progressive increase in wheel running, a reduced efficiency in food intake to compensate for their increased activity, and a severe progression of weight loss. Due to the parallelism with the clinical manifestations of anorexia nervosa including increased activity, reduced food intake and severe weight loss, the ABA procedure has been proposed as the best analog of human anorexia nervosa (AN). Thus, ABA research could both allow a better understanding of the mechanisms underlying AN and generate useful leads for treatment development in AN.

KEYWORDS:

activity-based anorexia; anorexia nervosa; food restriction; physical activity; self-starvation

PMID:
24723321
DOI:
10.1002/0471142301.ns0947s67
[Indexed for MEDLINE]
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