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Nat Rev Immunol. 2014 May;14(5):289-301. doi: 10.1038/nri3646. Epub 2014 Apr 11.

Mechanisms regulating skin immunity and inflammation.

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Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Z├╝lpicher Strasse 47a, 50674 Cologne, Germany.
Department of Dermatology, University of Cologne, Kerpener Strasse 62, D-50931 Cologne, Germany.
St John's Institute of Dermatology and Guy's and St Thomas' Hospital National Institute for Health Research Biomedical Research Centre, King's College London, SE1 9RT London, UK.


Immune responses in the skin are important for host defence against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic inflammatory skin diseases. Extensive crosstalk between the different cellular and microbial components of the skin regulates local immune responses to ensure efficient host defence, to maintain and restore homeostasis, and to prevent chronic disease. In this Review, we discuss recent findings that highlight the complex regulatory networks that control skin immunity, and we provide new paradigms for the mechanisms that regulate skin immune responses in host defence and in chronic inflammation.

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