Send to

Choose Destination
See comment in PubMed Commons below
Brain Res. 1988 Jun 7;451(1-2):261-73.

Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat.

Author information

  • 1Department of Pharmacology, John Curtin School of Medical Research, Australian National University, Canberra, A.C.T.


In barbiturate-anaesthetized spinal cats, antibody microprobes were used to examine immunoreactive substance P (irSP) release at sites within the spinal cord following cutaneous stimuli. A basal level of irSP release was detected in the region of the substantia gelatinosa of the lumbar spinal cord. No increase in this irSP release was produced by non-noxious thermal or mechanical cutaneous stimulation. Noxious thermal, mechanical or chemical cutaneous stimuli all increased release of irSP in the region of the substantia gelatinosa and in the overlying pia mater. The results support a role for SP in the transmission of information from nociceptors to spinal neurones.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk