Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroscience. 2014 Jun 6;269:343-66. doi: 10.1016/j.neuroscience.2014.03.063. Epub 2014 Apr 8.

From precursors to myelinating oligodendrocytes: contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain.

Author information

1
School of Psychology, University of Ottawa, Canada.
2
School of Psychology, University of Ottawa, Canada. Electronic address: cmessier@uottawa.ca.

Abstract

Oligodendrocyte precursor cells (OPC) are glial cells that metamorphose into myelinating oligodendrocytes during embryogenesis and early stages of post-natal life. OPCs continue to divide throughout adulthood and some eventually differentiate into oligodendrocytes in response to demyelinating lesions. There is growing evidence that OPCs are also involved in activity-driven de novo myelination of previously unmyelinated axons and myelin remodeling in adulthood. In this review, we summarize the interwoven factors and cascades that promote the activation, recruitment and differentiation of OPCs into myelinating oligodendrocytes in the adult brain based mostly on results found in the study of demyelinating diseases. The goal of the review was to draw a complete picture of the transformation of OPCs into mature oligodendrocytes to facilitate the study of this transformation in both the normal and diseased adult brain.

KEYWORDS:

multiple sclerosis; myelin; myelin remodeling; oligodendrocyte; plasticity; remyelination

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center