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Curr Opin Pharmacol. 2014 Apr;15:68-73. doi: 10.1016/j.coph.2013.12.003. Epub 2013 Dec 25.

TRPM4 channels in the cardiovascular system.

Author information

1
Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
2
Institute of Physiology, Universitätsklinikum des Saarlandes, Homburg, Germany. Electronic address: oupon@t-online.de.

Abstract

The non-selective Transient Receptor Potential Melastatin 4 (TRPM4) cation channel is abundantly expressed in cardiac cells, being involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarization. Dominantly inherited mutations in the TRPM4 gene are associated with the cardiac bundle-branch disorder progressive familial heart block type I (PFHBI) and isolated cardiac conduction disease (ICCD) giving rise to atrio-ventricular conduction block (AVB), right bundle branch block, bradycardia, and the Brugada syndrome. The mutant phenotypes closely resemble those associated with mutations in the SCN5A gene, encoding the voltage-gated Na(+) channel NaV1.5. These observations and the unexpected partnership with sulfonylurea-receptors (SURs) makes the TRPM4 channel a promising novel target for treatment of cardiac disorders.

PMID:
24721656
DOI:
10.1016/j.coph.2013.12.003
[Indexed for MEDLINE]

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