Send to

Choose Destination
Curr Opin Pharmacol. 2014 Apr;15:68-73. doi: 10.1016/j.coph.2013.12.003. Epub 2013 Dec 25.

TRPM4 channels in the cardiovascular system.

Author information

Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Institute of Physiology, Universitätsklinikum des Saarlandes, Homburg, Germany. Electronic address:


The non-selective Transient Receptor Potential Melastatin 4 (TRPM4) cation channel is abundantly expressed in cardiac cells, being involved in several aspects of cardiac rhythmicity, including cardiac conduction, pace making and action-potential repolarization. Dominantly inherited mutations in the TRPM4 gene are associated with the cardiac bundle-branch disorder progressive familial heart block type I (PFHBI) and isolated cardiac conduction disease (ICCD) giving rise to atrio-ventricular conduction block (AVB), right bundle branch block, bradycardia, and the Brugada syndrome. The mutant phenotypes closely resemble those associated with mutations in the SCN5A gene, encoding the voltage-gated Na(+) channel NaV1.5. These observations and the unexpected partnership with sulfonylurea-receptors (SURs) makes the TRPM4 channel a promising novel target for treatment of cardiac disorders.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center