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Epilepsy Res. 2014 Jul;108(5):986-8. doi: 10.1016/j.eplepsyres.2014.03.015. Epub 2014 Mar 27.

A multicenter survey of clinical experiences with perampanel in real life in Germany and Austria.

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Epilepsiezentrum Kork, Kehl, Kork, Germany. Electronic address:
Epilepsy Centre, University Hospital of Erlangen, Germany.
Neurological University Hospital of Salzburg, Austria.
Epilepsy Centre, University Hospital of Freiburg, Germany.
Bethel Epilepsie Center, Bielefeld-Bethel, Germany.
Saxonian Epilepsy Centre Dresden, Kleinwachau, Germany.
Zentrum Rosenhügel, Neurological Department, Vienna, Austria.
Neurological University Hospital, Tübingen, Germany.
Neurological University Hospital of München, Ludwig-Maximilians University, München, Germany.


Perampanel (PER) has been approved by the European Medicines Agency (EMA) for adjunctive treatment of patients with partial-onset seizures from age 12 years on. It has been introduced to the market in Germany and Austria in 2012. This cross-sectional observational study summarizes the clinical experience of nine centers with adjunctive PER. Patients were consecutively followed from the initiation of PER on. Only patients with a minimum observational period of six months (in case of ongoing treatment) were recruited. Efficacy data reflect the preceding three months at last observation, tolerability data were assessed at the last observation carried forward. 281 patients were included. After six months 169 were still on PER so that a retention rate of 60% resulted. 43 patients were seizure-free for the preceding 3 months (15%). Overall incidence of adverse events was 52.0%. The leading adverse events were somnolence (24.6%) and dizziness (19.6%) followed by ataxia (3.9%), aggression (2.8%), nausea (2.5%) and irritability (2.1%). We conclude that adjunctive PER may lead to at least temporary freedom of seizures in some of these highly difficult-to-treat patients. Adverse events are not uncommon.


Clinical experience; Epilepsy; Multicenter; Observational; Perampanel

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