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Alcohol. 2014 May;48(3):295-9. doi: 10.1016/j.alcohol.2014.02.002. Epub 2014 Mar 13.

Operant ethanol self-administration in ethanol dependent mice.

Author information

  • 1Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: lopezm@musc.edu.
  • 2Charleston Alcohol Research Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA; RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA.

Abstract

While rats have been predominantly used to study operant ethanol self-administration behavior in the context of dependence, several studies have employed operant conditioning procedures to examine changes in ethanol self-administration behavior as a function of chronic ethanol exposure and withdrawal experience in mice. This review highlights some of the advantages of using operant conditioning procedures for examining the motivational effects of ethanol in animals with a history of dependence. As reported in rats, studies using various operant conditioning procedures in mice have demonstrated significant escalation of ethanol self-administration behavior in mice rendered dependent via forced chronic ethanol exposure in comparison to nondependent mice. This paper also presents a summary of these findings, as well as suggestions for future studies.

KEYWORDS:

Ethanol dependence; Ethanol self-administration; Mice; Operant conditioning

PMID:
24721194
PMCID:
PMC4020177
DOI:
10.1016/j.alcohol.2014.02.002
[PubMed - indexed for MEDLINE]
Free PMC Article
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