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Commun Integr Biol. 2013 Nov 1;6(6):e27634. doi: 10.4161/cib.27634. Epub 2014 Jan 8.

Formin' cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamics.

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Institut für Neurobiologie; Universität Münster; Münster, Germany.
Bioinformatik, Biozentrum; Universität Würzburg; Würzburg, Germany.
Institut für Biochemie; Universitätsmedizin; Universität Göttingen; Göttingen, Germany.


Members of the Diaphanous (Dia) protein family are key regulators of fundamental actin driven cellular processes, which are conserved from yeast to humans. Researchers have uncovered diverse physiological roles in cell morphology, cell motility, cell polarity, and cell division, which are involved in shaping cells into tissues and organs. The identification of numerous binding partners led to substantial progress in our understanding of the differential functions of Dia proteins. Genetic approaches and new microscopy techniques allow important new insights into their localization, activity, and molecular principles of regulation.


Drosophila; actin; cytoskeleton; development; formin; nucleator

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