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J Natl Cancer Inst. 2014 Apr 9;106(5). pii: dju068. doi: 10.1093/jnci/dju068.

Dietary fat intake and development of specific breast cancer subtypes.

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Affiliations of authors: Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (SS, CA, VP, FB, SG, VK); Medical Statistics Unit, Second University of Naples, Naples, Italy (PC); Hellenic Health Foundation, Athens, Greece (ATr); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece (VB, EV); Escuela Andaluza de Salud Pública, Granada, Spain (M-JS); CIBER de Epidemiología y Salud Pública, Madrid, Spain (M-JS, M-DC, PA, EA); Instituto de Investigación Biosanitaria de Granada, Granada, Spain (M-JS); Department of Epidemiology, Murcia Health Authority, Murcia, Spain (M-DC); Public Health Division of Gipuzkoa, BioDonostia Research Institute, Health Department of Basque Region, San Sebastian, Spain (PA); Health Information Unit, Public Health and Health Planning Directorate, Asturias, Spain (JRQ); Navarre Public Health Institute, Pamplona, Spain (EA); Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Barcelona, Spain (GB); Molecular and Nutritional Epidemiology Unit, ISPO-Cancer Research and Prevention Institute, Florence, Italy (GM); Department of Clinical and Experimental Medicine, University of Naples Federico II, Naples, Italy (SP); Center for Cancer Prevention, Turin, Italy (CS); Human Genetics Foundation, Turin, Italy (CS); Department of Oncology, Histopathology Unit (RT), and Cancer Registry (RT), Ospedale Civile "M.P. Arezzo," Ragusa, Italy; INSERM, Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villejuif, France (MC-BR); Univ Paris Sud, UMRS 1018, F-94805, Villejuif, France (FC-C); IGR, F-94805, Villejuif, France (GF); Department of Epidemiology, Julius Center for Health Sciences and Primary Care (PHMP, CHvG), and Department of Gastroenterology and Hepatology (HBB-d-M), University Medical Center Utrecht, Utrecht, the Netherlands;


We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

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