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PLoS One. 2014 Apr 9;9(4):e94473. doi: 10.1371/journal.pone.0094473. eCollection 2014.

The pretreatment albumin to globulin ratio has predictive value for long-term mortality in nasopharyngeal carcinoma.

Author information

1
Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
2
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
3
Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.

Abstract

BACKGROUND:

Low serum albumin is predictive of poor survival in nasopharyngeal carcinoma (NPC). We evaluated the ability of the pretreatment albumin/globulin ratio (AGR) to predict long-term mortality in patients with NPC.

METHODS:

This retrospective study examined an unselected cohort of 694 patients with NPC who had documented pretreatment total serum protein and serum albumin levels (ALB). AGR was calculated as [AGR = ALB/(total serum protein--ALB)]. Survival analysis was used to evaluate the predictive value of AGR.

RESULTS:

Multivariate analysis demonstrated that a low pretreatment serum AGR (<1.4) was an independent predictor of poor OS (P  = 0.029) and DMFS (P  = 0.033). A low AGR was significantly associated with advanced stage disease (P<0.001), high white blood cell count (P  = 0.033), high neutrophil count (P  = 0.047), high total serum protein (P<0.001) and low ALB (P<0.001).

CONCLUSION:

The pretreatment AGR may represent a simple, potentially useful predictive biomarker for evaluating the long-term prognosis of patients with undifferentiated NPC.

PMID:
24718309
PMCID:
PMC3981820
DOI:
10.1371/journal.pone.0094473
[Indexed for MEDLINE]
Free PMC Article
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