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Nucleus. 2014 Mar-Apr;5(2):124-30. doi: 10.4161/nucl.28825. Epub 2014 Apr 9.

Stochastic genome-nuclear lamina interactions: modulating roles of Lamin A and BAF.

Author information

1
Division of Gene Regulation; Netherlands Cancer Institute; Amsterdam, the Netherlands.

Abstract

The nuclear lamina (NL) is thought to aid in the spatial organization of interphase chromosomes by providing an anchoring platform for hundreds of large genomic regions named lamina associated domains (LADs). Recently, a new live-cell imaging approach demonstrated directly that LAD-NL interactions are dynamic and in part stochastic. Here we discuss implications of these new findings and introduce Lamin A and BAF as potential modulators of stochastic LAD positioning.

KEYWORDS:

BAF; LADs; Lamin A; Lamin B1; chromatin domains; nuclear organization; single cell

PMID:
24717229
PMCID:
PMC4049918
DOI:
10.4161/nucl.28825
[Indexed for MEDLINE]
Free PMC Article
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