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Asian Pac J Cancer Prev. 2014;15(5):2379-81.

Anthocyanins: targeting of signaling networks in cancer cells.

Author information

  • 1Department of Medical Biochemistry, Canakkale Onsekiz Mart University, Canakkale, Turkey E-mail : hilals@comu.edu.tr ammadahmad638@yahoo.com.

Abstract

It is becoming progressively more understandable that phytochemicals derived from edible plants have shown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitro and in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. More intriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancer patients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluence of information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes. There is a successive increase in the research-work in nutrigenomics and evidence has started to shed light on intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring to limelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.

PMID:
24716988
[PubMed - indexed for MEDLINE]
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