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Asian Pac J Cancer Prev. 2014;15(5):2191-4.

A systemic analysis of S-1 regimens for treatment of patients with colon cancer.

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1
Department of Oncological Surgery, Shaanxi Provincial People's Hospital, Xi'an, China E-mail : xianzhangen@126.com.

Abstract

BACKGROUND:

Fluorouracil-based regimens have been widely accepted and recommended in the guidelines for treating patients with early or advanced staged colon cancer, although results are controversial. Here we performed a systemic analysis to evaluate the impact of S-1 based regimens on response and survival of patients with colon cancer.

METHODS:

Clinical studies evaluating the impact of S-1 based regimens on response and survival of patients with colon cancer were identified using a predefined search strategy. Summary response rates (RRs) to treatment were calculated.

RESULTS:

Six clinical studies which including 227 patients with advanced colorectal cancer were considered eligible for inclusion. Two studies were conducted using combination of S-1 and Oxaliplatin, and four studies featured S-1 and irinotecan. Systemic analysis showed that, in all patients, pooled RRs was 43.17%. Major adverse effects were hematological toxicities, gastrointestinal disturbance, neurosensory toxicity. No treatment related death occurred.

CONCLUSION:

This systemic analysis suggests that S-1 based regimens, both with oxaliplatin or irinotean are associated with acceptable response and toxicity in patients with colon cancer.

PMID:
24716955
[Indexed for MEDLINE]
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