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Nat Prod Res. 2014;28(14):1091-8. doi: 10.1080/14786419.2014.907287. Epub 2014 Apr 9.

Composition of the essential oil of the Rhododendron tomentosum Harmaja from Estonia.

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a Department of Pharmacy , University of Tartu , Nooruse 1, 50411 Tartu , Estonia.


Wild Rhododendron tomentosum Harmaja shoots were collected from four localities of Estonia. Essential oils, isolated from dried samples by simultaneous distillation and extraction, were analysed using GC-FID and Gas chromatography-mass spectrometry methods. The yields of oils were in the range 0.14-0.87%. A total of 72 constituents, accounting for over 95% of the total oil yield, were identified. The major components in the all four oils studied were palustrol (15.9-53.5%), ledol (11.8-18.3%), γ-terpineol (0-31.2%), p-cymene (0.1-13.9%), lepalone (0.7-6.5%), lepalol (1.0-6.5%) and cyclocolorenone (1.0-6.4%). Two different chemotypes of R. tomentosum were found in Estonia and one of them was rich in palustrol (41.0-53.5%) and ledol (14.6-18.3%). The second chemotype, for the first time, was rich in γ-terpineol (24.7-31.2%) and contained less of palustrol (15.9-16.7%) and ledol (11.8-12.8%), but more p-cymene (12.5-13.9%). Also, γ-terpineol was identified for the first time in the oils of R. tomentosum.


Ledum palustre L.; Rhododendrum tomentosum Harmaja; chemotypes; essential oil; ledol; marsh rosemary; palustrol

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